Pharmacology and Nutritional Sciences           Barnstable Brown Obesity and Research Day                    Equipment Calendars              

The Phase III Center of Research in Obesity and Cardiovascular Disease (COCVD) at the University of Kentucky is supported by a $5.7 million, five-year award (P30 GM127211) from the National Institute of General Medical Sciences (NIGMS). The NIGMS is a part of the National Institutes of Health (NIH) that supports thematic, multidisciplinary Centers of Biomedical Research Excellence (COBRE) across the country through its Institutional Development Award (IDeA) program.

The primary activity of the COCVD is to identify mechanisms linking the epidemic of obesity to the high incidence of cardiovascular diseases in the obese population. This research focus is used as a platform to develop promising junior investigators who serve as principal investigators on research projects that address timely and significant questions related to obesity and cardiovascular disease. COCVD has assembled a group of established extramurally funded scientists who provide mentoring for the investigators. This mentorship facilitates the development of the investigators’ research projects and enhances their success in competing for independent NIH-funded research.

As a multidisciplinary collaborative, COCVD encourages the development of research infrastructure and shared use core facilities that support and extend research methods critical to the study of obesity and cardiovascular disease. Additionally, COCVD facilitates symposia and seminars for its research participants, and awards pilot/feasibility grants to non-COCVD faculty members to initiate new research focused on obesity and cardiovascular disease.

Research Support Services and Equipment
It is imperative that all users of COBRE Core services and/or equipment, including radiotelemetry, EchoMRI, DEXA-IR, metabolism chambers, pathology services, MS or bioplex analytical services and the statistical analysis that Dr. Katherine Thompson provides, must cite the COBRE NIH grant using this language as an example:  

"Research reported in this [publication, release] was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P30 GM127211.”
Before utilizing research equipment on the fifth floor of the CT Wethington Building and other locations, please review this overview on the use and handling of equipment.

Recent Publications

1: Guo Y, Ye Q, Deng P, Cao Y, He D, Zhou Z, Wang C, Zaytseva YY, Schwartz CE,
Lee EY, Mark Evers B, Morris AJ, Liu S, She QB. Spermine synthase and MYC
cooperate to maintain colorectal cancer cell survival by repressing Bim
expression. Nat Commun. 2020 Jun 26;11(1):3243. doi: 10.1038/s41467-020-17067-x.
PMID: 32591507; PMCID: PMC7320137.

2: Chalfant JM, Howatt DA, Tannock LR, Daugherty A, Pendergast JS. Circadian
disruption with constant light exposure exacerbates atherosclerosis in male
ApolipoproteinE-deficient mice. Sci Rep. 2020 Jun 18;10(1):9920. doi:
10.1038/s41598-020-66834-9. PMID: 32555251; PMCID: PMC7303111.

3: Davis KA, Peng H, Chelvarajan L, Abdel-Latif A, Berron BJ. Increased yield of
gelatin coated therapeutic cells through cholesterol insertion. J Biomed Mater
Res A. 2020 Jun 3. doi: 10.1002/jbm.a.37025. Epub ahead of print. PMID:

4: Mahanes TM, Murphy MO, Ouyang A, Yiannikouris FB, Fleenor BS, Loria AS.
Maternal separation-induced increases in vascular stiffness are independent of
circulating angiotensinogen levels. J Appl Physiol (1985). 2020 Jul
1;129(1):58-65. doi: 10.1152/japplphysiol.00703.2019. Epub 2020 May 14. PMID:

5: Ratajczak MZ, Bujko K, Cymer M, Thapa A, Adamiak M, Ratajczak J, Abdel-Latif
AK, Kucia M. The Nlrp3 inflammasome as a "rising star" in studies of normal and
malignant hematopoiesis. Leukemia. 2020 Jun;34(6):1512-1523. doi:
10.1038/s41375-020-0827-8. Epub 2020 Apr 20. PMID: 32313108; PMCID: PMC7266743.

6: Sui Y, Meng Z, Park SH, Lu W, Livelo C, Chen Q, Zhou T, Zhou C. Myeloid-
specific deficiency of pregnane X receptor decreases atherosclerosis in LDL
receptor-deficient mice. J Lipid Res. 2020 May;61(5):696-706. doi:
10.1194/jlr.RA119000122. Epub 2020 Mar 13. PMID: 32170024; PMCID: PMC7193955.

7: Martínez-Martínez AB, Torres-Perez E, Devanney N, Del Moral R, Johnson LA,
Arbones-Mainar JM. Beyond the CNS: The many peripheral roles of APOE. Neurobiol
Dis. 2020 May;138:104809. doi: 10.1016/j.nbd.2020.104809. Epub 2020 Feb 19.
PMID: 32087284; PMCID: PMC7195217.

8: Finlin BS, Memetimin H, Zhu B, Confides AL, Vekaria HJ, El Khouli RH, Johnson
ZR, Westgate PM, Chen J, Morris AJ, Sullivan PG, Dupont-Versteegden EE, Kern PA.
The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in
obese humans. J Clin Invest. 2020 May 1;130(5):2319-2331. doi:
10.1172/JCI134892. PMID: 31961829; PMCID: PMC7190997.

9: Williams HC, Farmer BC, Piron MA, Walsh AE, Bruntz RC, Gentry MS, Sun RC,
Johnson LA. APOE alters glucose flux through central carbon pathways in
astrocytes. Neurobiol Dis. 2020 Mar;136:104742. doi: 10.1016/j.nbd.2020.104742.
Epub 2020 Jan 11. PMID: 31931141; PMCID: PMC7044721.

10: Johnson LA. APOE at the BBB: Pericyte-Derived Apolipoprotein E4 Diminishes
Endothelial Cell Barrier Function. Arterioscler Thromb Vasc Biol. 2020
Jan;40(1):14-16. doi: 10.1161/ATVBAHA.119.313627. Epub 2019 Dec 23. PMID:
31869265; PMCID: PMC7001796.

11: Che C, Dudick K, Shoemaker R. Cardiac hypertrophy with obesity is augmented
after pregnancy in C57BL/6 mice. Biol Sex Differ. 2019 Dec 16;10(1):59. doi:
10.1186/s13293-019-0269-z. PMID: 31842996; PMCID: PMC6916003.

12: Lifsey HC, Kaur R, Thompson BH, Bennett L, Temel RE, Graf GA. Stigmasterol
stimulates transintestinal cholesterol excretion independent of liver X receptor
activation in the small intestine. J Nutr Biochem. 2020 Feb;76:108263. doi:
10.1016/j.jnutbio.2019.108263. Epub 2019 Nov 9. PMID: 31759199; PMCID:

13: El-Helw M, Chelvarajan L, Abo-Aly M, Soliman M, Milburn G, Conger AL,
Campbell K, Ratajczak MZ, Abdel-Latif A. Identification of Human Very Small
Embryonic like Stem Cells (VSELS) in Human Heart Tissue Among Young and Old
Individuals. Stem Cell Rev Rep. 2020 Feb;16(1):181-185. doi:
10.1007/s12015-019-09923-1. PMID: 31758373; PMCID: PMC7027381.

14: Dalmasso C, Leachman JR, Ensor CM, Yiannikouris FB, Giani JF, Cassis LA,
Loria AS. Female Mice Exposed to Postnatal Neglect Display Angiotensin II-
Dependent Obesity-Induced Hypertension. J Am Heart Assoc. 2019 Dec
3;8(23):e012309. doi: 10.1161/JAHA.119.012309. Epub 2019 Nov 22. PMID: 31752639;
PMCID: PMC6912962.

15: Omotola O, Legan S, Slade E, Adekunle A, Pendergast JS. Estradiol regulates
daily rhythms underlying diet-induced obesity in female mice. Am J Physiol
Endocrinol Metab. 2019 Dec 1;317(6):E1172-E1181. doi:
10.1152/ajpendo.00365.2019. Epub 2019 Nov 5. PMID: 31689145; PMCID: PMC6957379.

16: Strattan E, Palaniyandi S, Kumari R, Du J, Hakim N, Huang T, Kesler MV,
Jennings CD, Sturgill JL, Hildebrandt GC. Mast Cells Are Mediators of Fibrosis
and Effector Cell Recruitment in Dermal Chronic Graft-vs.-Host Disease. Front
Immunol. 2019 Oct 18;10:2470. doi: 10.3389/fimmu.2019.02470. PMID: 31681336;
PMCID: PMC6813249.

17: Zein AA, Kaur R, Hussein TOK, Graf GA, Lee JY. ABCG5/G8: a structural view
to pathophysiology of the hepatobiliary cholesterol secretion. Biochem Soc
Trans. 2019 Oct 31;47(5):1259-1268. doi: 10.1042/BST20190130. PMID: 31654053;
PMCID: PMC6824678.

18: Deng P, Hoffman JB, Petriello MC, Wang CY, Li XS, Kraemer MP, Morris AJ,
Hennig B. Dietary inulin decreases circulating ceramides by suppressing neutral
sphingomyelinase expression and activity in mice. J Lipid Res. 2020
Jan;61(1):45-53. doi: 10.1194/jlr.RA119000346. Epub 2019 Oct 11. PMID: 31604806;
PMCID: PMC6939596.

19: Mueller PA, Yang L, Ubele M, Mao G, Brandon J, Vandra J, Nichols TC,
Escalante-Alcalde D, Morris AJ, Smyth SS. Coronary Artery Disease Risk-
Associated <i>Plpp3</i> Gene and Its Product Lipid Phosphate Phosphatase 3
Regulate Experimental Atherosclerosis. Arterioscler Thromb Vasc Biol. 2019
Nov;39(11):2261-2272. doi: 10.1161/ATVBAHA.119.313056. Epub 2019 Sep 19. PMID:
31533471; PMCID: PMC6812632.

20: Shoemaker R, Tannock LR, Su W, Gong M, Gurley SB, Thatcher SE, Yiannikouris
F, Ensor CM, Cassis LA. Adipocyte deficiency of ACE2 increases systolic blood
pressures of obese female C57BL/6 mice. Biol Sex Differ. 2019 Sep 4;10(1):45.
doi: 10.1186/s13293-019-0260-8. PMID: 31484552; PMCID: PMC6727421