About COCVD


The Phase II Center of Research in Obesity and Cardiovascular Disease (COCVD) at the University of Kentucky is supported by a $11.3 million, five-year award (P20 GM103527) from the National Institute of General Medical Sciences (NIGMS). The NIGMS is a part of the National Institutes of Health (NIH) that supports thematic, multidisciplinary Centers of Biomedical Research Excellence (COBRE) across the country through its Institutional Development Award (IDeA) program.

The primary activity of the COCVD is to identify mechanisms linking the epidemic of obesity to the high incidence of cardiovascular diseases in the obese population. This research focus is used as a platform to develop promising junior investigators who serve as principal investigators on research projects that address timely and significant questions related to obesity and cardiovascular disease. COCVD has assembled a group of established extramurally funded scientists who provide mentoring for the investigators. This mentorship facilitates the development of the investigators’ research projects and enhances their success in competing for independent NIH-funded research.

As a multidisciplinary collaborative, COCVD encourages the development of research infrastructure and shared use core facilities that support and extend research methods critical to the study of obesity and cardiovascular disease. Additionally, COCVD facilitates symposia and seminars for its research participants, and awards pilot/feasibility grants to non-COCVD faculty members to initiate new research focused on obesity and cardiovascular disease.

Research Support Services and Equipment
It is imperative that all users of COBRE Core services and/or equipment, including radiotelemetry, EchoMRI, DEXA-IR, metabolism chambers, pathology services, MS or bioplex analytical services and the statistical analysis that Dr. Richard Charnigo or Dr. Katherine Thompson provide, must cite the COBRE NIH grant using this language as an example:  

"Research reported in this [publication, release] was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P20GM103527.”
  
Before utilizing research equipment on the fifth floor of the CT Wethington Building and other locations, please review this overview on the use and handling of equipment.

Recent Publications

Rotroff DM, Pijut SS, Marvel SW, Jack JR, Havener TM, Pujol A, Schluter A, Graf GA, Ginsberg HN, Shah HS, Gao H, Morieri ML, Doria A, Mychaleckyi JC, McLeod HL, Buse JB, Wagner MJ, Motsinger-Reif AA; ACCORD/ACCORDion Investigators. Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes. Clin Pharmacol Ther. 2018 Apr;103(4):712-721. doi: 10.1002/cpt.798. Epub 2017 Nov 3. PubMed PMID:28736931; PubMed Central PMCID: PMC5828950.

Sui Y, Park SH, Wang F, Zhou C. Perinatal Bisphenol A Exposure Increases Atherosclerosis in Adult Male PXR-Humanized Mice. Endocrinology. 2018 Apr 1;159(4):1595-1608. doi: 10.1210/en.2017-03250. PubMed PMID: 29425287.

Tannock LR, De Beer MC, Ji A, Shridas P, Noffsinger VP, den Hartigh L, Chait A, De Beer FC, Webb NR. Serum amyloid A3 is a high density lipoprotein-associated acute-phase protein. J Lipid Res. 2018 Feb;59(2):339-347. doi:10.1194/jlr.M080887. Epub 2017 Dec 15. PubMed PMID: 29247043; PubMed Central
PMCID: PMC5794427.

Sui Y, Liu Z, Park SH, Thatcher SE, Zhu B, Fernandez JP, Molina H, Kern PA, Zhou C. IKKβ is a β-catenin kinase that regulates mesenchymal stem cell differentiation. JCI Insight. 2018 Jan 25;3(2). pii: 96660. doi:
10.1172/jci.insight.96660. [Epub ahead of print] PubMed PMID: 29367460; PubMed Central PMCID: PMC5821193.

Alsiraj Y, Thatcher SE, Blalock E, Fleenor B, Daugherty A, Cassis LA. Sex Chromosome Complement Defines Diffuse Versus Focal Angiotensin II-Induced Aortic Pathology. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):143-153. doi:10.1161/ATVBAHA.117.310035. Epub 2017 Nov 2. PubMed PMID: 29097367.

Thompson JC, Wilson PG, Wyllie AP, Wyllie AK, Tannock LR. Elevated circulating TGF-β is not the cause of increased atherosclerosis development in biglycan deficient mice. Atherosclerosis. 2018 Jan;268:68-75. doi:
10.1016/j.atherosclerosis.2017.11.005. Epub 2017 Nov 10. PubMed PMID: 29182988;
PubMed Central PMCID: PMC5750111.

Thompson JC, Wilson PG, Shridas P, Ji A, de Beer M, de Beer FC, Webb NR, Tannock LR. Serum amyloid A3 is pro-atherogenic. Atherosclerosis. 2018 Jan;268:32-35. doi: 10.1016/j.atherosclerosis.2017.11.011. Epub 2017 Nov 17. PubMed PMID: 29175652; PubMed Central PMCID: PMC5839639.

Wilson PG, Thompson JC, Yoder MH, Charnigo R, Tannock LR. Prevention of renal apoB retention is protective against diabetic nephropathy: role of TGF-β inhibition. J Lipid Res. 2017 Dec;58(12):2264-2274. doi: 10.1194/jlr.M078204. Epub 2017 Sep 14. PubMed PMID: 28912302; PubMed Central PMCID: PMC5711490.

Wahlang B, Barney J, Thompson B, Wang C, Hamad OM, Hoffman JB, Petriello MC, Morris AJ, Hennig B. Editor's Highlight: PCB126 Exposure Increases Risk for Peripheral Vascular Diseases in a Liver Injury Mouse Model. Toxicol Sci. 2017 Dec 1;160(2):256-267. doi: 10.1093/toxsci/kfx180. PubMed PMID: 28973532; PubMed Central PMCID: PMC5837513.

Rush JS, Edgar RJ, Deng P, Chen J, Zhu H, van Sorge NM, Morris AJ, Korotkov KV, Korotkova N. The molecular mechanism of N-acetylglucosamine side-chain attachment to the Lancefield group A carbohydrate in Streptococcus pyogenes. J Biol Chem. 2017 Nov 24;292(47):19441-19457. doi: 10.1074/ jbc.M117.815910. Epub 2017 Oct 11. PubMed PMID: 29021255; PubMed Central PMCID: PMC5702681.

Pendergast JS, Wendroth RH, Stenner RC, Keil CD, Yamazaki S. mPeriod2 (Brdm1) and other single Period mutant mice have normal food anticipatory activity. Sci Rep. 2017 Nov 14;7(1):15510. doi: 10.1038/s41598-017-15332-6. PubMed PMID:29138421; PubMed Central PMCID:  PMC5686205.

Jing L, Nevius CD, Friday CM, Suever JD, Pulenthiran A, Mejia-Spiegeler A, Kirchner HL, Cochran WJ, Wehner GJ, Chishti AS, Haggerty CM, Fornwalt BK. Ambulatory systolic blood pressure and obesity are independently associated with left ventricular hypertrophic remodeling in children. J Cardiovasc Magn Reson. 2017 Nov 9;19(1):86. doi: 10.1186/s12968-017-0401-3. PubMed PMID: 29117866;
PubMed Central PMCID: PMC5679494.

Dong A, Mueller P, Yang F, Yang L, Morris A, Smyth SS. Direct thrombin inhibition with dabigatran attenuates pressure overload-induced cardiac fibrosis and dysfunction in mice. Thromb Res. 2017 Nov;159:58-64. doi:10.1016/j.thromres.2017.09.016. Epub 2017 Sep 21. PubMed PMID: 28982031; PubMed
Central PMCID: PMC5722681.

Muniappan L, Javidan A, Jiang W, Mohammadmoradi S, Moorleghen JJ, Katz WS, Balakrishnan A, Howatt DA, Subramanian V. Calpain Inhibition Attenuates Adipose Tissue Inflammation and Fibrosis in Diet-induced Obese Mice. Sci Rep. 2017 Oct 31;7(1):14398. doi: 10.1038/s41598-017-14719-9. PubMed PMID: 29089532; PubMed Central PMCID: PMC5663911.

Shridas P, Noffsinger VP, Trumbauer AC, Webb NR. The dual role of group V secretory phospholipase A(2) in pancreatic β-cells. Endocrine. 2017 Oct;58(1):47-58. doi: 10.1007/s12020-017-1379-1. Epub 2017 Aug 19. PubMed PMID: 28825176; PubMed Central PMCID: PMC5693688.

Finlin BS, Zhu B, Kok BP, Godio C, Westgate PM, Grayson N, Sims R, Bland JS, Saez E, Kern PA. The Influence of a KDT501, a Novel Isohumulone, on Adipocyte Function in Humans. Front Endocrinol (Lausanne). 2017 Sep 29;8:255. doi:10.3389/fendo.2017.00255. eCollection 2017. PubMed PMID: 29033896; PubMed Central PMCID: PMC5626816.

Bradford EM, Ryu SH, Singh AP, Lee G, Goretsky T, Sinh P, Williams DB, Cloud AL, Gounaris E, Patel V, Lamping OF, Lynch EB, Moyer MP, De Plaen IG, Shealy DJ, Yang GY, Barrett TA. Epithelial TNF Receptor Signaling Promotes Mucosal Repair in Inflammatory Bowel Disease. J Immunol. 2017 Sep 1;199(5):1886-1897. doi:10.4049/jimmunol.1601066. Epub 2017 Jul 26. PubMed PMID: 28747340; PubMed Central
PMCID: PMC5568528.

Kim S, Yang L, Kim S, Lee RG, Graham MJ, Berliner JA, Lusis AJ, Cai L, Temel RE, Rateri DL, Lee S. Targeting hepatic heparin-binding EGF-like growth factor (HB-EGF) induces anti-hyperlipidemia leading to reduction of angiotensin II-induced aneurysm development. PLoS One. 2017 Aug 9;12(8):e0182566. doi:10.1371/ journal.pone.0182566. eCollection 2017. PubMed PMID: 28792970; PubMed Central PMCID: PMC5549937.

Adamiak M, Chelvarajan L, Lynch KR, Santos WL, Abdel-Latif A, Ratajczak MZ. Mobilization studies in mice deficient in sphingosine kinase 2 support a crucial role of the plasma level of sphingosine-1-phosphate in the egress of hematopoietic stem progenitor cells. Oncotarget. 2017 Jul 24;8(39):65588-65600.
doi: 10.18632/oncotarget.19514. eCollection 2017 Sep 12. PubMed PMID: 29029455;
PubMed Central PMCID: PMC5630355.

Akenhead ML, Fukuda S, Schmid-Schönbein GW, Shin HY. Fluid shear-induced cathepsin B release in the control of Mac1-dependent neutrophil adhesion. J Leukoc Biol. 2017 Jul;102(1):117-126. doi:10.1189/ jlb.3A0716-317RR. Epub 2017 Apr 7. PubMed PMID: 28389621; PubMed Central PMCID: PMC5470839.

Jing L, Pulenthiran A, Nevius CD, Mejia-Spiegeler A, Suever JD, Wehner GJ, Kirchner HL, Haggerty CM, Fornwalt BK. Impaired right ventricular contractile function in childhood obesity and its association with right and left ventricular changes: a cine DENSE cardiac magnetic resonance study. J Cardiovasc Magn Reson. 2017 Jun 28;19(1):49. doi: 10.1186/s12968-017-0363-5. PubMed PMID: 28659144;
PubMed Central PMCID: PMC5490166.

Brown JM, Temel RE, Graf GA. Para-bile-osis Establishes a Role for Nonbiliary Macrophage to Feces Reverse Cholesterol Transport. Arterioscler Thromb Vasc Biol. 2017 May;37(5):738-739. doi: 10.1161/ATVBAHA.117.309224. PubMed PMID: 28446467; PubMed Central PMCID: PMC5546086.

Arnold AP, Cassis LA, Eghbali M, Reue K, Sandberg K. Sex Hormones and Sex Chromosomes Cause Sex Differences in the Development of Cardiovascular Diseases. Arterioscler Thromb Vasc Biol. 2017 May;37(5):746-756. doi:10.1161/ATVBAHA.116.307301. Epub 2017 Mar 9. Review. PubMed PMID: 28279969;
PubMed Central PMCID: PMC5437981.

Finlin BS, Zhu B, Confides AL, Westgate PM, Harfmann BD, Dupont-Versteegden EE, Kern PA. Mast Cells Promote Seasonal White Adipose Beiging in Humans. Diabetes. 2017 May;66(5):1237-1246. doi: 10.2337/db16-1057. Epub 2017 Mar 1. PubMed PMID: 28250021; PubMed Central PMCID: PMC5399616.

Suever JD, Wehner GJ, Jing L, Powell DK, Hamlet SM, Grabau JD, Mojsejenko D, Andres KN, Haggerty CM, Fornwalt BK. Right Ventricular Strain, Torsion, and Dyssynchrony in Healthy Subjects Using 3D Spiral Cine DENSE Magnetic Resonance Imaging. IEEE Trans Med Imaging. 2017 May;36(5):1076-1085. doi:10.1109/ TMI.2016.2646321. Epub 2016 Dec 29. PubMed PMID: 28055859; PubMed Central PMCID: PMC5711416.