About COCVD

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The Phase II Center of Research in Obesity and Cardiovascular Disease (COCVD) at the University of Kentucky is supported by a $11.3 million, five-year award (P30 GM127211) from the National Institute of General Medical Sciences (NIGMS). The NIGMS is a part of the National Institutes of Health (NIH) that supports thematic, multidisciplinary Centers of Biomedical Research Excellence (COBRE) across the country through its Institutional Development Award (IDeA) program.

The primary activity of the COCVD is to identify mechanisms linking the epidemic of obesity to the high incidence of cardiovascular diseases in the obese population. This research focus is used as a platform to develop promising junior investigators who serve as principal investigators on research projects that address timely and significant questions related to obesity and cardiovascular disease. COCVD has assembled a group of established extramurally funded scientists who provide mentoring for the investigators. This mentorship facilitates the development of the investigators’ research projects and enhances their success in competing for independent NIH-funded research.

As a multidisciplinary collaborative, COCVD encourages the development of research infrastructure and shared use core facilities that support and extend research methods critical to the study of obesity and cardiovascular disease. Additionally, COCVD facilitates symposia and seminars for its research participants, and awards pilot/feasibility grants to non-COCVD faculty members to initiate new research focused on obesity and cardiovascular disease.

Research Support Services and Equipment
It is imperative that all users of COBRE Core services and/or equipment, including radiotelemetry, EchoMRI, DEXA-IR, metabolism chambers, pathology services, MS or bioplex analytical services and the statistical analysis that Dr. Richard Charnigo or Dr. Katherine Thompson provide, must cite the COBRE NIH grant using this language as an example:  

"Research reported in this [publication, release] was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P30 GM127211.”
  
Before utilizing research equipment on the fifth floor of the CT Wethington Building and other locations, please review this overview on the use and handling of equipment.

Recent Publications

1: Wehner GJ, Jing L, Haggerty CM, Suever JD, Chen J, Hamlet SM, Feindt JA, Dimitri Mojsejenko W, Fogel MA, Fornwalt BK. Comparison of left ventricular strains and torsion derived from feature tracking and DENSE CMR. J Cardiovasc Magn Reson. 2018 Sep 13;20(1):63. doi: 10.1186/s12968-018-0485-4. PubMed PMID:30208894; PubMed Central PMCID: PMC6136226.

2: Finlin BS, Memetimin H, Confides AL, Kasza I, Zhu B, Vekaria HJ, Harfmann B, Jones KA, Johnson ZR, Westgate PM, Alexander CM, Sullivan PG, Dupont-Versteegden EE, Kern PA. Human adipose beiging in response to cold and mirabegron. JCI Insight. 2018 Aug 9;3(15). pii: 121510. doi: 10.1172/jci.insight.121510. [Epub ahead of print] PubMed PMID: 30089732; PubMed Central PMCID: PMC6129119.

3: Dong L, Ren H. Blood-based DNA Methylation Biomarkers for Early Detection of Colorectal Cancer. J Proteomics Bioinform. 2018;11(6):120-126. doi:10.4172/jpb.1000477. Epub 2018 Jun 26. PubMed PMID: 30034186; PubMed Central PMCID: PMC6054487.

4: Al-Darraji A, Haydar D, Chelvarajan L, Tripathi H, Levitan B, Gao E, Venditto VJ, Gensel JC, Feola DJ, Abdel-Latif A. Azithromycin therapy reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction: Potential therapeutic targets in ischemic heart disease. PLoS One.
2018 Jul 12;13(7):e0200474. doi: 10.1371/journal.pone.0200474. eCollection 2018 PubMed PMID: 30001416; PubMed Central PMCID: PMC6042749

5: Wilson PG, Thompson JC, Shridas P, McNamara PJ, de Beer MC, de Beer FC, Webb NR, Tannock LR. Serum Amyloid A Is an Exchangeable Apolipoprotein. Arterioscler Thromb Vasc Biol. 2018 Jul 5. pii: ATVBAHA.118.310979. doi:10.1161/ATVBAHA.118.310979. [Epub] PubMed PMID: 29976766.

6: Shridas P, De Beer MC, Webb NR. High-density lipoprotein inhibits serum amyloid A-mediated reactive oxygen species generation and NLRP3 inflammasome activation. J Biol Chem. 2018 Aug 24;293(34):13257-13269. doi:10.1074/jbc.RA118.002428. Epub 2018 Jul 5. PubMed PMID: 29976759; PubMed Central
PMCID: PMC6109913

7: Brandon JA, Farmer BC, Williams HC, Johnson LA. APOE and Alzheimer's Disease: Neuroimaging of Metabolic and Cerebrovascular Dysfunction. Front Aging Neurosci. 2018 Jun 14;10:180. doi:10.3389/ fnagi .2018.00180. eCollection 2018. PubMed PMID:29962946; PubMed Central PMCID: PMC6010552.

8: Klyachkin YM, Idris A, Rodell CB, Tripathi H, Ye S, Nagareddy P, Asfour A, Gao E, Annabathula R, Ratajczak M, Burdick JA, Abdel-Latif A. Cathelicidin Related Antimicrobial Peptide (CRAMP) Enhances Bone Marrow Cell Retention and Attenuates Cardiac Dysfunction in a Mouse Model of Myocardial Infarction. Stem Cell Rev. 2018 Oct;14(5):702-714. doi: 10.1007/s12015-018-9833-x. PubMed PMID: 29948752;
PubMed Central PMCID: PMC6119631.

9: Alshudukhi AA, Zhu J, Huang D, Jama A, Smith JD, Wang QJ, Esser KA, Ren H. Lipin-1 regulates Bnip3-mediated mitophagy in glycolytic muscle. FASEB J. 2018 Jun 25:fj201800374. doi: 10.1096/fj.201800374. [Epub ahead of print] PubMed PMID:29939786.

10: Manning JR, Chelvarajan L, Levitan BM, Withers CN, Nagareddy PR, Haggerty CM, Fornwalt BK, Gao E, Tripathi H, Abdel-Latif A, Andres DA, Satin J. Rad GTPase deletion attenuates post-ischemic cardiac dysfunction and remodeling. JACC Basic Transl Sci. 2018 Feb;3(1):83-96. doi: 10.1016/j.jacbts.2017.09.004. PubMed PMID: 29732439; PubMed Central PMCID: PMC5931223.

11: Adamiak M, Bujko K, Cymer M, Plonka M, Glaser T, Kucia M, Ratajczak J, Ulrich H, Abdel-Latif A, Ratajczak MZ. Novel evidence that extracellular nucleotides and purinergic signaling induce innate immunity-mediated mobilization of hematopoietic stem/progenitor cells. Leukemia. 2018 Sep;32(9):1920-1931. doi:10.1038/s41375-018-0122-0. Epub 2018 Mar 30 PubMed PMID: 29725032; PubMed Central PMCID: PMC6127086

12: Wang F, Liu Z, Park SH, Gwag T, Lu W, Ma M, Sui Y, Zhou C. Myeloid β-Catenin Deficiency Exacerbates Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1468-1478. doi: 10.1161/ATVBAHA.118.311059. Epub 2018 May 3. PubMed PMID: 29724817; PubMed Central PMCID: PMC6023740.

13: Stewart BD, Scott CE, McCoy TP, Yin G, Despa F, Despa S, Kekenes-Huskey PM. Computational modeling of amylin-induced calcium dysregulation in rat ventricular cardiomyocytes. Cell Calcium. 2018 May;71:65-74. doi: 10.1016/j.ceca.2017.11.006. Epub 2017 Dec 8. PubMed PMID: 29604965; PubMed Central PMCID: PMC5881945.

14: Meier S, Gilad AA, Brandon JA, Qian C, Gao E, Abisambra JF, Vandsburger M. Non-invasive detection of adeno-associated viral gene transfer using a genetically encoded CEST-MRI reporter gene in the murine heart. Sci Rep. 2018 Mar 15;8(1):4638. doi: 10.1038/s41598-018-22993-4. PubMed PMID: 29545551; PubMed Central PMCID: PMC5854573.

15: Murphy MO, Herald JB, Leachman J, Villasante Tezanos A, Cohn DM, Loria AS. A model of neglect during postnatal life heightens obesity-induced hypertension and is linked to a greater metabolic compromise in female mice. Int J Obes (Lond). 2018 Jul;42(7):1354-1365. doi: 10.1038/s41366-018-0035-z. Epub 2018 Feb 23. PubMed PMID: 29535450; PubMed Central PMCID: PMC6054818.

16: Sui Y, Park SH, Wang F, Zhou C. Perinatal Bisphenol A Exposure Increases Atherosclerosis in Adult Male PXR-Humanized Mice. Endocrinology. 2018 Apr 1;159(4):1595-1608. doi: 10.1210/en.2017-03250. PubMed PMID: 29425287; PubMed Central PMCID: PMC5939635.

17: Sui Y, Liu Z, Park SH, Thatcher SE, Zhu B, Fernandez JP, Molina H, Kern PA, Zhou C. IKKβ is a β-catenin kinase that regulates mesenchymal stem cell differentiation. JCI Insight. 2018 Jan 25;3(2). pii: 96660. doi:
10.1172/jci.insight.96660. [Epub ahead of print] PubMed PMID: 29367460; PubMed Central PMCID: PMC5821193.

18: Tannock LR, De Beer MC, Ji A, Shridas P, Noffsinger VP, den Hartigh L, Chait A, De Beer FC, Webb NR. Serum amyloid A3 is a high density lipoprotein-associated acute-phase protein. J Lipid Res. 2018 Feb;59(2):339-347. doi:10.1194/jlr.M080887 Epub 2017 Dec 15. PubMed PMID: 29247043; PubMed Central PMCID: PMC5794427.

19: Thompson JC, Wilson PG, Wyllie AP, Wyllie AK, Tannock LR. Elevated circulating TGF-β is not the cause of increased atherosclerosis development in biglycan deficient mice. Atherosclerosis. 2018 Jan;268:68-75. doi:10.1016/j.atherosclerosis.2017.11.005. Epub 2017 Nov 10. PubMed PMID: 29182988;PubMed Central PMCID: PMC5750111.

20: Thompson JC, Wilson PG, Shridas P, Ji A, de Beer M, de Beer FC, Webb NR, Tannock LR. Serum amyloid A3 is pro-atherogenic. Atherosclerosis. 2018 Jan;268:32-35. doi: 10.1016/j.atherosclerosis.2017.11.011. Epub 2017 Nov 17. PubMed PMID: 29175652; PubMed Central PMCID: PMC5839639.

21: Lee SJ, Zea R, Kim DH, Lubner MG, Deming DA, Pickhardt PJ. CT texture features of liver parenchyma for predicting development of metastatic disease and overall survival in patients with colorectal cancer. Eur Radiol. 2018 Apr;28(4):1520-1528. doi: 10.1007/s00330-017-5111-6. Epub 2017 Nov 21. PubMed PMID: 29164382.

22: Pendergast JS, Wendroth RH, Stenner RC, Keil CD, Yamazaki S. mPeriod2 (Brdm1) and other single Period mutant mice have normal food anticipatory activity. Sci Rep. 2017 Nov 14;7(1):15510. doi: 10.1038/s41598-017-15332-6. PubMed PMID:29138421; PubMed Central PMCID: PMC5686205.

23: Jing L, Nevius CD, Friday CM, Suever JD, Pulenthiran A, Mejia-Spiegeler A, Kirchner HL, Cochran WJ, Wehner GJ, Chishti AS, Haggerty CM, Fornwalt BK. Ambulatory systolic blood pressure and obesity are independently associated with left ventricular hypertrophic remodeling in children. J Cardiovasc Magn Reson. 2017 Nov 9;19(1):86. doi: 10.1186/s12968-017-0401-3. PubMed PMID: 29117866;
PubMed Central PMCID: PMC5679494.

24: Alsiraj Y, Thatcher SE, Blalock E, Fleenor B, Daugherty A, Cassis LA. Sex Chromosome Complement Defines Diffuse Versus Focal Angiotensin II-Induced Aortic Pathology. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):143-153. doi:10.1161/ATVBAHA.117.310035. Epub 2017 Nov 2. PubMed PMID: 29097367; PubMed Central PMCID: PMC5864127.

25: Muniappan L, Javidan A, Jiang W, Mohammadmoradi S, Moorleghen JJ, Katz WS, Balakrishnan A, Howatt DA, Subramanian V. Calpain Inhibition Attenuates Adipose Tissue Inflammation and Fibrosis in Diet-induced Obese Mice. Sci Rep. 2017 Oct 31;7(1):14398. doi: 10.1038/s41598-017-14719-9. PubMed PMID: 29089532; PubMed Central PMCID: PMC5663911.