Pharmacology and Nutritional Sciences           Barnstable Brown Obesity and Research Day                    Equipment Calendars              

The Phase III Center of Research in Obesity and Cardiovascular Disease (COCVD) at the University of Kentucky is supported by a $5.7 million, five-year award (P30 GM127211) from the National Institute of General Medical Sciences (NIGMS). The NIGMS is a part of the National Institutes of Health (NIH) that supports thematic, multidisciplinary Centers of Biomedical Research Excellence (COBRE) across the country through its Institutional Development Award (IDeA) program.

The primary activity of the COCVD is to identify mechanisms linking the epidemic of obesity to the high incidence of cardiovascular diseases in the obese population. This research focus is used as a platform to develop promising junior investigators who serve as principal investigators on research projects that address timely and significant questions related to obesity and cardiovascular disease. COCVD has assembled a group of established extramurally funded scientists who provide mentoring for the investigators. This mentorship facilitates the development of the investigators’ research projects and enhances their success in competing for independent NIH-funded research.

As a multidisciplinary collaborative, COCVD encourages the development of research infrastructure and shared use core facilities that support and extend research methods critical to the study of obesity and cardiovascular disease. Additionally, COCVD facilitates symposia and seminars for its research participants, and awards pilot/feasibility grants to non-COCVD faculty members to initiate new research focused on obesity and cardiovascular disease.

Research Support Services and Equipment
It is imperative that all users of COBRE Core services and/or equipment, including radiotelemetry, EchoMRI, DEXA-IR, metabolism chambers, pathology services, MS or bioplex analytical services and the statistical analysis that Dr. Katherine Thompson provides, must cite the COBRE NIH grant using this language as an example:  

"Research reported in this [publication, release] was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P30 GM127211.”
Before utilizing research equipment on the fifth floor of the CT Wethington Building and other locations, please review this overview on the use and handling of equipment.

Recent Publications

1: Che C, Dudick K, Shoemaker R. Cardiac hypertrophy with obesity is augmented
after pregnancy in C57BL/6 mice. Biol Sex Differ. 2019 Dec 16;10(1):59. doi:
10.1186/s13293-019-0269-z. PubMed PMID: 31842996; PubMed Central PMCID:

2: Omotola O, Legan S, Slade E, Adekunle A, Pendergast JS. Estradiol regulates
daily rhythms underlying diet-induced obesity in female mice. Am J Physiol
Endocrinol Metab. 2019 Dec 1;317(6):E1172-E1181. doi: 10.1152/ajpendo.00365.2019.
Epub 2019 Nov 5. PubMed PMID: 31689145.

3: El-Helw M, Chelvarajan L, Abo-Aly M, Soliman M, Milburn G, Conger AL, Campbell
K, Ratajczak MZ, Abdel-Latif A. Identification of Human Very Small Embryonic like
Stem Cells (VSELS) in Human Heart Tissue Among Young and Old Individuals. Stem
Cell Rev Rep. 2019 Nov 22. doi: 10.1007/s12015-019-09923-1. [Epub ahead of print]
PubMed PMID: 31758373.

4: Mueller PA, Yang L, Ubele M, Mao G, Brandon J, Vandra J, Nichols TC,
Escalante-Alcalde D, Morris AJ, Smyth SS. Coronary Artery Disease Risk-Associated
Plpp3 Gene and Its Product Lipid Phosphate Phosphatase 3 Regulate Experimental
Atherosclerosis. Arterioscler Thromb Vasc Biol. 2019 Nov;39(11):2261-2272. doi:
10.1161/ATVBAHA.119.313056. Epub 2019 Sep 19. PubMed PMID: 31533471; PubMed
Central PMCID: PMC6812632.

5: Li J, Pijut SS, Wang Y, Ji A, Kaur R, Temel RE, van der Westhuyzen DR, Graf
GA. Simultaneous Determination of Biliary and Intestinal Cholesterol Secretion
Reveals That CETP (Cholesteryl Ester Transfer Protein) Alters Elimination Route
in Mice. Arterioscler Thromb Vasc Biol. 2019 Oct;39(10):1986-1995. doi:
10.1161/ATVBAHA.119.312952. Epub 2019 Aug 29. PubMed PMID: 31462090; PubMed
Central PMCID: PMC6761010.

6: Gatineau E, Gong MC, Yiannikouris F. Soluble Prorenin Receptor Increases Blood
Pressure in High Fat-Fed Male Mice. Hypertension. 2019 Oct;74(4):1014-1020. doi:
10.1161/HYPERTENSIONAHA.119.12906. Epub 2019 Aug 5. PubMed PMID: 31378099; PubMed
Central PMCID: PMC6739191.

7: Shoemaker R, Tannock LR, Su W, Gong M, Gurley SB, Thatcher SE, Yiannikouris F,
Ensor CM, Cassis LA. Adipocyte deficiency of ACE2 increases systolic blood
pressures of obese female C57BL/6 mice. Biol Sex Differ. 2019 Sep 4;10(1):45.
doi: 10.1186/s13293-019-0260-8. PubMed PMID: 31484552; PubMed Central PMCID:

8: Javidan A, Jiang W, Okuyama M, Thiagarajan D, Yang L, Moorleghen JJ, Muniappan
L, Subramanian V. miR-146a Deficiency Accelerates Hepatic Inflammation Without
Influencing Diet-induced Obesity in Mice. Sci Rep. 2019 Sep 2;9(1):12626. doi:
10.1038/s41598-019-49090-4. PubMed PMID: 31477775; PubMed Central PMCID:

9: Henson D, Tahhan AS, Nardo D, Quyyumi AA, Venditto VJ. Association Between
ApoA-I (Apolipoprotein A-I) Immune Complexes and Adverse Cardiovascular
Events-Brief Report. Arterioscler Thromb Vasc Biol. 2019 Sep;39(9):1884-1892.
doi: 10.1161/ATVBAHA.119.312964. Epub 2019 Jul 18. PubMed PMID: 31315438; PubMed
Central PMCID: PMC6703929.

10: Misumida N, Ogunbayo GO, Catanzaro J, Etaee F, Kim SM, Abdel-Latif A, Ziada
KM, Elayi CS. Contemporary practice pattern of permanent pacing for conduction
disorders in inferior ST-elevation myocardial infarction. Clin Cardiol. 2019
Aug;42(8):728-734. doi: 10.1002/clc.23210. Epub 2019 Jun 7. PubMed PMID:
31173380; PubMed Central PMCID: PMC6671775.

11: Larian N, Ensor M, Thatcher SE, English V, Morris AJ, Stromberg A, Cassis LA.
Pseudomonas aeruginosa-derived pyocyanin reduces adipocyte differentiation, body
weight, and fat mass as mechanisms contributing to septic cachexia. Food Chem
Toxicol. 2019 Aug;130:219-230. doi: 10.1016/j.fct.2019.05.012. Epub 2019 May 9.
PubMed PMID: 31078726; PubMed Central PMCID: PMC6557674.

12: Park SY, Yang JS, Li Z, Deng P, Zhu X, Young D, Ericsson M, Andringa RLH,
Minnaard AJ, Zhu C, Sun F, Moody DB, Morris AJ, Fan J, Hsu VW. The late stage of
COPI vesicle fission requires shorter forms of phosphatidic acid and
diacylglycerol. Nat Commun. 2019 Jul 30;10(1):3409. doi:
10.1038/s41467-019-11324-4. PubMed PMID: 31363100; PubMed Central PMCID:

13: Ahern BM, Levitan BM, Veeranki S, Shah M, Ali N, Sebastian A, Su W, Gong MC,
Li J, Stelzer JE, Andres DA, Satin J. Myocardial-restricted ablation of the
GTPase RAD results in a pro-adaptive heart response in mice. J Biol Chem. 2019
Jul 12;294(28):10913-10927. doi: 10.1074/jbc.RA119.008782. Epub 2019 May 30.
PubMed PMID: 31147441; PubMed Central PMCID: PMC6635439.

14: Jackson EN, Thatcher SE, Larian N, English V, Soman S, Morris AJ, Weng J,
Stromberg A, Swanson HI, Pearson K, Cassis LA. Effects of Aryl Hydrocarbon
Receptor Deficiency on PCB-77-Induced Impairment of Glucose Homeostasis during
Weight Loss in Male and Female Obese Mice. Environ Health Perspect. 2019
Jul;127(7):77004. doi: 10.1289/EHP4133. Epub 2019 Jul 15. PubMed PMID: 31306034;
PubMed Central PMCID: PMC6794491.

15: AlGhuraibawi W, Stromp T, Holtkamp R, Lam B, Rehwald W, Leung SW, Vandsburger
M. CEST MRI reveals a correlation between visceral fat mass and reduced
myocardial creatine in obese individuals despite preserved ventricular structure
and function. NMR Biomed. 2019 Jul;32(7):e4104. doi: 10.1002/nbm.4104. Epub 2019
May 15. PubMed PMID: 31094042; PubMed Central PMCID: PMC6581603.

16: Brown AJ, Pendergast JS, Yamazaki S. Peripheral Circadian Oscillators. Yale J
Biol Med. 2019 Jun 27;92(2):327-335. eCollection 2019 Jun. Review. PubMed PMID:
31249493; PubMed Central PMCID: PMC6585520.

17: Wu C, Lu W, Zhang Y, Zhang G, Shi X, Hisada Y, Grover SP, Zhang X, Li L,
Xiang B, Shi J, Li XA, Daugherty A, Smyth SS, Kirchhofer D, Shiroishi T, Shao F,
Mackman N, Wei Y, Li Z. Inflammasome Activation Triggers Blood Clotting and Host
Death through Pyroptosis. Immunity. 2019 Jun 18;50(6):1401-1411.e4. doi:
10.1016/j.immuni.2019.04.003. Epub 2019 May 7. PubMed PMID: 31076358; PubMed
Central PMCID: PMC6791531.

18: Lu W, Park SH, Meng Z, Wang F, Zhou C. Deficiency of Adipocyte IKKβ Affects
Atherosclerotic Plaque Vulnerability in Obese LDLR Deficient Mice. J Am Heart
Assoc. 2019 Jun 18;8(12):e012009. doi: 10.1161/JAHA.119.012009. Epub 2019 Jun 15.
PubMed PMID: 31203708; PubMed Central PMCID: PMC6645619.

19: Finlin BS, Confides AL, Zhu B, Boulanger MC, Memetimin H, Taylor KW, Johnson
ZR, Westgate PM, Dupont-Versteegden EE, Kern PA. Adipose Tissue Mast Cells
Promote Human Adipose Beiging in Response to Cold. Sci Rep. 2019 Jun
17;9(1):8658. doi: 10.1038/s41598-019-45136-9. PubMed PMID: 31209239; PubMed
Central PMCID: PMC6572779.

20: AlSiraj Y, Chen X, Thatcher SE, Temel RE, Cai L, Blalock E, Katz W, Ali HM,
Petriello M, Deng P, Morris AJ, Wang X, Lusis AJ, Arnold AP, Reue K, Thompson K,
Tso P, Cassis LA. XX sex chromosome complement promotes atherosclerosis in mice.
Nat Commun. 2019 Jun 14;10(1):2631. doi: 10.1038/s41467-019-10462-z. PubMed PMID:
31201301; PubMed Central PMCID: PMC6643208.

21: Misumida N, Pagath M, Ogunbayo GO, Wilson RE, Kim SM, Abdel-Latif A, Elayi
CS. Characteristics of and current practice patterns of pacing for high-degree
atrioventricular block after transcatheter aortic valve implantation in
comparison to surgical aortic valve replacement. Catheter Cardiovasc Interv. 2019
Jun 1;93(7):E385-E390. doi: 10.1002/ccd.27915. Epub 2018 Oct 9. PubMed PMID:
30302907; PubMed Central PMCID: PMC6660647.

22: Gottipati A, Chelvarajan L, Peng H, Kong R, Cahall CF, Li C, Tripathi H,
Al-Darraji A, Ye S, Elsawalhy E, Abdel-Latif A, Berron BJ. Gelatin Based Polymer
Cell Coating Improves Bone Marrow-Derived Cell Retention in the Heart after
Myocardial Infarction. Stem Cell Rev Rep. 2019 Jun;15(3):404-414. doi:
10.1007/s12015-018-9870-5. PubMed PMID: 30644039; PubMed Central PMCID:

23: Shoemaker R, AlSiraj Y, Chen J, Cassis LA. Pancreatic AT1aR Deficiency
Decreases Insulin Secretion in Obese C57BL/6 Mice. Am J Hypertens. 2019 May
9;32(6):597-604. doi: 10.1093/ajh/hpz042. PubMed PMID: 30903169; PubMed Central
PMCID: PMC6508375.

24: Johnson LA, Torres ER, Weber Boutros S, Patel E, Akinyeke T, Alkayed NJ,
Raber J. Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular
dysfunction and the post-prandial response. J Cereb Blood Flow Metab. 2019
May;39(5):770-781. doi: 10.1177/0271678X17746186. Epub 2017 Dec 7. PubMed PMID:
29215310; PubMed Central PMCID: PMC6498752.

25: Gwag T, Meng Z, Sui Y, Helsley RN, Park SH, Wang S, Greenberg RN, Zhou C.
Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce
hypercholesterolemia and hepatic steatosis. J Hepatol. 2019 May;70(5):930-940.
doi: 10.1016/j.jhep.2018.12.038. Epub 2019 Jan 21. PubMed PMID: 30677459; PubMed
Central PMCID: PMC6462244.