Pharmacology and Nutritional SciencesBarnstable Brown Obesity and Research Day          Equipment Calendars              

The Phase II Center of Research in Obesity and Cardiovascular Disease (COCVD) at the University of Kentucky is supported by a $11.3 million, five-year award (P20 GM103527) from the National Institute of General Medical Sciences (NIGMS). The NIGMS is a part of the National Institutes of Health (NIH) that supports thematic, multidisciplinary Centers of Biomedical Research Excellence (COBRE) across the country through its Institutional Development Award (IDeA) program.

The primary activity of the COCVD is to identify mechanisms linking the epidemic of obesity to the high incidence of cardiovascular diseases in the obese population. This research focus is used as a platform to develop promising junior investigators who serve as principal investigators on research projects that address timely and significant questions related to obesity and cardiovascular disease. COCVD has assembled a group of established extramurally funded scientists who provide mentoring for the investigators. This mentorship facilitates the development of the investigators’ research projects and enhances their success in competing for independent NIH-funded research.

As a multidisciplinary collaborative, COCVD encourages the development of research infrastructure and shared use core facilities that support and extend research methods critical to the study of obesity and cardiovascular disease. Additionally, COCVD facilitates symposia and seminars for its research participants, and awards pilot/feasibility grants to non-COCVD faculty members to initiate new research focused on obesity and cardiovascular disease.

Research Support Services and Equipment
It is imperative that all users of COBRE Core services and/or equipment, including radiotelemetry, EchoMRI, DEXA-IR, metabolism chambers, pathology services, MS or bioplex analytical services and the statistical analysis that Dr. Richard Charnigo provides, must cite the COBRE NIH grant using this language as an example:  

"Research reported in this [publication, release] was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P20GM103527.”
Before utilizing research equipment on the fifth floor of the CT Wethington Building and other locations, please review this overview on the use and handling of equipment.

Recent Publications

An interactive videogame designed to improve respiratory navigator efficiency in children undergoing cardiovascular magnetic resonance.

Hamlet SM, Haggerty CM, Suever JD, Wehner GJ, Grabau JD, Andres KN, Vandsburger MH, Powell DK, Sorrell VL, Fornwalt BK.

J Cardiovasc Magn Reson. 2016 Sep 6;18(1):54. doi: 10.1186/s12968-016-0272-z.

Long-Term Outcomes and Causes of Death in Patients With Renovascular Disease Undergoing Renal Artery Stenting.

Wallace EL, Tasan E, Cook BS, Charnigo R, Abdel-Latif AK, Ziada KM.
Angiology. 2016 Aug;67(7):657-63. doi: 10.1177/0003319715609013.

Oligonucleotide-induced alternative splicing of serotonin 2C receptor reduces food intake.
Zhang Z, Shen M, Gresch PJ, Ghamari-Langroudi M, Rabchevsky AG, Emeson RB, Stamm S.
EMBO Mol Med. 2016 Aug 1;8(8):878-94. doi: 10.15252/emmm.201506030.

Optimal configuration of respiratory navigator gating for the quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI.
Hamlet SM, Haggerty CM, Suever JD, Wehner GJ, Andres KN, Powell DK, Zhong X, Fornwalt BK.
J Magn Reson Imaging. 2016 Jul 26. doi: 10.1002/jmri.25389.

Short-Term Dietary Restriction Rescues Mice From Lethal Abdominal Sepsis and Endotoxemia and Reduces the Inflammatory/Coagulant Potential of Adipose Tissue.
Starr ME, Steele AM, Cohen DA, Saito H.
Crit Care Med. 2016 Jul;44(7):e509-19. doi: 10.1097/CCM.0000000000001475.

Structure and functions of angiotensinogen.

Lu H, Cassis LA, Kooi CW, Daugherty A.

Hypertens Res. 2016 Jul;39(7):492-500. doi: 10.1038/hr.2016.17. Review.

Adipocyte (Pro)Renin-Receptor Deficiency Induces Lipodystrophy, Liver Steatosis and Increases Blood Pressure in Male Mice.

Wu CH, Mohammadmoradi S, Thompson J, Su W, Gong M, Nguyen G, Yiannikouris F.
Hypertension. 2016 Jul;68(1):213-9. doi: 10.1161/HYPERTENSIONAHA.115.06954.

Targeting IκB kinase β in Adipocyte Lineage Cells for Treatment of Obesity and Metabolic Dysfunctions.

Helsley RN, Sui Y, Park SH, Liu Z, Lee RG, Zhu B, Kern PA, Zhou C.
Stem Cells. 2016 Jul;34(7):1883-95. doi: 10.1002/stem.2358.

Effect of peripheral circadian dysfunction on metabolic disease in response to a diabetogenic diet.
Pijut SS, Corbett DE, Wang Y, Li J, Charnigo RJ, Graf GA.
Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E900-11. doi: 10.1152/ajpendo.00328.2015.

IKKβ Is Essential for Adipocyte Survival and Adaptive Adipose Remodeling in Obesity.

Park SH, Liu Z, Sui Y, Helsley RN, Zhu B, Powell DK, Kern PA, Zhou C.
Diabetes. 2016 Jun;65(6):1616-29. doi: 10.2337/db15-1156.

Impact of individual acute phase serum amyloid A isoforms on HDL metabolism in mice.

Kim MH, de Beer MC, Wroblewski JM, Charnigo RJ, Ji A, Webb NR, de Beer FC, van der Westhuyzen DR.
J Lipid Res. 2016 Jun;57(6):969-79. doi: 10.1194/jlr.M062174.

Cardiac remodeling and dysfunction in childhood obesity: a cardiovascular magnetic resonance study.

Jing L, Binkley CM, Suever JD, Umasankar N, Haggerty CM, Rich J, Wehner GJ, Hamlet SM, Powell DK, Radulescu A, Kirchner HL, Epstein FH, Fornwalt BK.     J Cardiovasc Magn Reson. 2016 May 11;18(1):28. doi: 10.1186/s12968-016-0247-0.

An obligatory role for neurotensin in high-fat-diet-induced obesity.

Li J, Song J, Zaytseva YY, Liu Y, Rychahou P, Jiang K, Starr ME, Kim JT, Harris JW, Yiannikouris FB, Katz WS, Nilsson PM, Orho-Melander M, Chen J, Zhu H, Fahrenholz T, Higashi RM, Gao T, Morris AJ, Cassis LA, Fan TW, Weiss HL, Dobner PR, Melander O, Jia J, Evers BM.

Nature. 2016 May 11;533(7603):411-5. doi: 10.1038/nature17662.

Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice.

Howatt DA, Balakrishnan A, Moorleghen JJ, Muniappan L, Rateri DL, Uchida HA, Takano J, Saido TC, Chishti AH, Baud L, Subramanian V.

Arterioscler Thromb Vasc Biol. 2016 May;36(5):835-45. doi: 10.1161/ATVBAHA.116.307285.

Evidence that a lipolytic enzyme--hematopoietic-specific phospholipase C-β2--promotes mobilization of hematopoietic stem cells by decreasing their lipid raft-mediated bone marrow retention and increasing the promobilizing effects of granulocytes.

Adamiak M, Poniewierska-Baran A, Borkowska S, Schneider G, Abdelbaset-Ismail A, Suszynska M, Abdel-Latif A, Kucia M, Ratajczak J, Ratajczak MZ.

Leukemia. 2016 Apr;30(4):919-28. doi: 10.1038/leu.2015.315.

Muscle-specific loss of Bmal1 leads to disrupted tissue glucose metabolism and systemic glucose homeostasis.

Harfmann BD, Schroder EA, Kachman MT, Hodge BA, Zhang X, Esser KA.
Skelet Muscle. 2016 Mar 30;6:12. doi: 10.1186/s13395-016-0082-x.

Safety of an abbreviated duration of dual antiplatelet therapy (≤6 months) following second-generation drug-eluting stents for coronary artery disease: A systematic review and meta-analysis of randomized trials.

Ziada KM, Abdel-Latif A, Charnigo R, Moliterno DJ.
Catheter Cardiovasc Interv. 2016 Mar;87(4):722-32. doi: 10.1002/ccd.26110.

A Cytosolic Multiprotein Complex Containing p85α Is Required for β-Catenin Activation in Colitis and Colitis-associated Cancer.

Goretsky T, Bradford EM, Ryu H, Tahir M, Moyer MP, Gao T, Li L, Barrett TA.

J Biol Chem. 2016 Feb 19;291(8):4166-77. doi: 10.1074/jbc.M115.669416.

Angiotensinogen Exerts Effects Independent of Angiotensin II.

Lu H, Wu C, Howatt DA, Balakrishnan A, Moorleghen JJ, Chen X, Zhao M, Graham MJ, Mullick AE, Crooke RM, Feldman DL, Cassis LA, Vander Kooi CW, Daugherty A.     Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):256-65. doi: 10.1161/ATVBAHA.115.306740.

Exercise protects against PCB-induced inflammation and associated cardiovascular risk factors.

Murphy MO, Petriello MC, Han SG, Sunkara M, Morris AJ, Esser K, Hennig B.

Environ Sci Pollut Res Int. 2016 Feb;23(3):2201-11. doi: 10.1007/s11356-014-4062-6.